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P300 asymmetry and positive symptom severity: a study in the early stage of a first episode of psychosis.
- Source :
-
Schizophrenia research [Schizophr Res] 2007 Jul; Vol. 93 (1-3), pp. 366-73. Date of Electronic Publication: 2007 May 10. - Publication Year :
- 2007
-
Abstract
- The amplitude of the P300 event-related potential (ERP) has been reported to be reduced over left compared to right temporal sites in schizophrenia patients. This left temporal P300 reduction has been associated with positive symptom severity and gray matter reduction in the left superior temporal gyrus. We investigated a group of patients with a first episode of schizophrenia spectrum psychosis and a group of normal controls to verify if P300 amplitude asymmetry already exists around the time of presentation for treatment. Relative to normal control subjects, no P300 asymmetry was found in patients. Nevertheless, P300 asymmetry was correlated with the severity of positive symptoms and worse global functioning (GAF), a good predictor of poor outcome.
- Subjects :
- Adolescent
Adult
Attention physiology
Delusions diagnosis
Delusions physiopathology
Delusions psychology
Early Diagnosis
Female
Humans
Male
Pitch Perception physiology
Psychotic Disorders diagnosis
Psychotic Disorders psychology
Schizophrenia diagnosis
Schizotypal Personality Disorder physiopathology
Schizotypal Personality Disorder psychology
Statistics as Topic
Temporal Lobe physiopathology
Cerebral Cortex physiopathology
Dominance, Cerebral physiology
Event-Related Potentials, P300 physiology
Psychiatric Status Rating Scales
Psychotic Disorders physiopathology
Schizophrenia physiopathology
Schizophrenic Psychology
Schizotypal Personality Disorder diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0920-9964
- Volume :
- 93
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 17498929
- Full Text :
- https://doi.org/10.1016/j.schres.2007.03.024