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HLA-G 14-bp polymorphism at exon 8 in Amerindian populations from the Brazilian Amazon.
- Source :
-
Tissue antigens [Tissue Antigens] 2007 Mar; Vol. 69 (3), pp. 255-60. - Publication Year :
- 2007
-
Abstract
- HLA-G (human leukocyte antigen-G) plays an important role in the modulation of the maternal immune system during pregnancy. HLA-G alleles presenting a 14-bp insertion at exon 8 have been associated with decreased messenger RNA levels, preeclampsia, and miscarriages. This suggests that natural selection may exert a strong influence against the insertion allele in isolated populations. DNA samples from 384 Amazonian Indians spread across seven isolated tribes were evaluated for the 14-bp polymorphism. The insertion frequency (38.54%) was somewhat low. The Ewens-Watterson's neutrality test showed a slight trend toward balancing selection operating at this locus but no correlation between the 14-bp locus and fertility data was found. To sum up, no definitive evidence was obtained indicating that the 14-bp frequencies in Amerindians depart from neutrality.
Details
- Language :
- English
- ISSN :
- 0001-2815
- Volume :
- 69
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Tissue antigens
- Publication Type :
- Academic Journal
- Accession number :
- 17493150
- Full Text :
- https://doi.org/10.1111/j.1399-0039.2006.00797.x