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Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study.
- Source :
-
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2007 Oct; Vol. 18 (10), pp. 1337-44. Date of Electronic Publication: 2007 May 11. - Publication Year :
- 2007
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Abstract
- Unlabelled: We examined the associations of metabolic syndrome (MS) with BMD, osteoporosis, and osteoporotic fractures in 417 men and 671 women from the Rancho Bernardo Study. After adjusting for BMI, MS was associated with lower, not higher BMD. Incidence of osteoporotic non-vertebral fractures was higher in participants with MS. MS may be another risk factor for osteoporotic fractures.<br />Introduction: The metabolic syndrome (MS) is a cluster of risk factors, including abdominal obesity, high glucose, triglycerides, hypertension and low HDL levels, associated with cardiovascular disease morbidity. The association between components of the MS and bone mineral density (BMD) has been researched, but results are contradictory.<br />Methods: We used multivariate regression models to examine the cross-sectional associations of MS defined by NCEP-ATP III criteria with BMD and osteoporosis, and the longitudinal association of MS with fractures in 420 men and 676 women from the Rancho Bernardo Study.<br />Results: Prevalence of MS at baseline was 23.5% in men and 18.2% in women. In age-adjusted analyses, men and women with MS had higher BMD at total hip when compared to those without MS (p < 0.001 and p = 0.01, respectively). Men but not women with MS also had higher BMD at femoral neck (p = 0.05). After adjusting for BMI, these associations were reversed, such that MS was associated with lower and not higher BMD.<br />Conclusion: Incidence of osteoporotic non-vertebral fractures was higher in participants with MS. MS may be another risk factor for osteoporotic fractures. The association of MS with higher BMD was explained by the higher BMI in those with MS.
- Subjects :
- Aged
Cohort Studies
Cross-Sectional Studies
Female
Fractures, Bone physiopathology
Fractures, Bone therapy
Humans
Male
Metabolic Syndrome diagnosis
Metabolic Syndrome physiopathology
Osteoporosis metabolism
Osteoporosis physiopathology
Prevalence
Risk Factors
Sex Factors
Bone Density physiology
Fractures, Bone etiology
Metabolic Syndrome complications
Osteoporosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0937-941X
- Volume :
- 18
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Publication Type :
- Academic Journal
- Accession number :
- 17492393
- Full Text :
- https://doi.org/10.1007/s00198-007-0385-1