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Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jun 15; Vol. 17 (12), pp. 3491-6. Date of Electronic Publication: 2007 Jan 25. - Publication Year :
- 2007
-
Abstract
- A number of RXR modulators with novel structural features were synthesized and screened in the functional assays. The synthesis and the structure-activity relationship within the series of compounds will be presented. Some in vivo data generated in the models for dyslipidemia and diabetes will also be presented.
- Subjects :
- Animals
Disease Models, Animal
Hypoglycemic Agents chemical synthesis
Hypoglycemic Agents therapeutic use
Quinolones chemical synthesis
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Diabetes Mellitus drug therapy
Dyslipidemias drug therapy
Hypoglycemic Agents pharmacology
Quinolones pharmacology
Retinoid X Receptors agonists
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17490875
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.01.049