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Tumor suppresser gene p53 expression in premalignant lesions and gastric carcinoma - prognostic value.
- Source :
-
Bosnian journal of basic medical sciences [Bosn J Basic Med Sci] 2007 Feb; Vol. 7 (1), pp. 7-10. - Publication Year :
- 2007
-
Abstract
- The aim of the study was to verify the presence of mutated tumor suppresser gene p53 in intestinal mucosa with histologically confirmed premalignant lesions and gastric carcinoma, and assess its prognostic value. The paper presents prospective study that included 50 patients with gastric adeno-carcinoma of intestinal type that were treated at Gastroenterohepatology Clinic, and 50 patients with histologically confirmed chronic atrophic H. pylori positive gastritis. In the mucosa biopsy samples, we analyzed presence, frequency and severity of inflammatory-regenerative, metaplastic and dysplastic changes. We typed intestinal metaplasia immunohistochemically and confirmed the presence of p53 onco-protein in antigen positive gastric carcinoma cells, and evaluated its prognostic value. Our results suggest that H. pylori acts as an initiator of inflammatory processes in gastric mucosa, which are followed by emergence of precancerous lesions. p53 is expressed late in carcinogenesis (14%) and as such, may be considered as an indicator of transformation of premalignant into malignant lesion.
- Subjects :
- Adenocarcinoma pathology
Gastritis, Atrophic pathology
Humans
Intestinal Mucosa pathology
Metaplasia metabolism
Metaplasia pathology
Precancerous Conditions pathology
Predictive Value of Tests
Prognosis
Prospective Studies
Severity of Illness Index
Stomach Neoplasms pathology
Adenocarcinoma metabolism
Gastritis, Atrophic metabolism
Intestinal Mucosa metabolism
Precancerous Conditions metabolism
Stomach Neoplasms metabolism
Tumor Suppressor Protein p53 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1512-8601
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bosnian journal of basic medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 17489760
- Full Text :
- https://doi.org/10.17305/bjbms.2007.3080