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Multiple biomarkers in molecular oncology. II. Molecular diagnostics applications in breast cancer management.
- Source :
-
Expert review of molecular diagnostics [Expert Rev Mol Diagn] 2007 May; Vol. 7 (3), pp. 269-80. - Publication Year :
- 2007
-
Abstract
- In recent years, the application of genomic and proteomic technologies to the problem of breast cancer prognosis and the prediction of therapy response have begun to yield encouraging results. Independent studies employing transcriptional profiling of primary breast cancer specimens using DNA microarrays have identified gene expression profiles that correlate with clinical outcome in primary breast biopsy specimens. Recent advances in microarray technology have demonstrated reproducibility, making clinical applications more achievable. In this regard, one such DNA microarray device based upon a 70-gene expression signature was recently cleared by the US FDA for application to breast cancer prognosis. These DNA microarrays often employ at least 70 gene targets for transcriptional profiling and prognostic assessment in breast cancer. The use of PCR-based methods utilizing a small subset of genes has recently demonstrated the ability to predict the clinical outcome in early-stage breast cancer. Furthermore, protein-based immunohistochemistry methods have progressed from using gene clusters and gene expression profiling to smaller subsets of expressed proteins to predict prognosis in early-stage breast cancer. Beyond prognostic applications, DNA microarray-based transcriptional profiling has demonstrated the ability to predict response to chemotherapy in early-stage breast cancer patients. In this review, recent advances in the use of multiple markers for prognosis of disease recurrence in early-stage breast cancer and the prediction of therapy response will be discussed.
- Subjects :
- Biomarkers, Tumor biosynthesis
Biomarkers, Tumor genetics
Breast Neoplasms genetics
Breast Neoplasms pathology
Drug Delivery Systems methods
Female
Gene Expression Regulation, Neoplastic drug effects
Humans
Oligonucleotide Array Sequence Analysis methods
Practice Guidelines as Topic
Prognosis
Biomarkers, Tumor analysis
Breast Neoplasms diagnosis
Breast Neoplasms drug therapy
Drug Delivery Systems trends
Oligonucleotide Array Sequence Analysis trends
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8352
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Expert review of molecular diagnostics
- Publication Type :
- Academic Journal
- Accession number :
- 17489734
- Full Text :
- https://doi.org/10.1586/14737159.7.3.269