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[Evaluation of the performance of immunological parameters as indicators for clinical progression of chronic HTLV-1 infection].
- Source :
-
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2007 Jan-Feb; Vol. 40 (1), pp. 29-36. - Publication Year :
- 2007
-
Abstract
- This study evaluated the performance of single and combined laboratory parameters, B-lymphocyte percentages (%LB), T/B cell ratio and %CD8+HLA-DR+/CD8+, to differentiate asymptomatic cases (AS) from HAM/TSP patients (HT) within a population of HTLV-1 seropositive cases. Percentage indices demonstrated that each parameter alone presented moderate performance, with co-negativity of 83 and 91% for %LB and T/B cell ratio, respectively, and co-positivity of 78% for %CD8+HLA-DR+/CD8+. Combined analysis (%CD8+HLA-DR+/CD8+ and T/B cell ratio) did not show any substantial performance enhancement (co-positivity = 75% and co-negativity = 74%). Likelihood ratio analysis using different value ranges for the separate parameters revealed that HTLV-1 seropositive cases with %LB<7%, T/B cell ratio>11 and %CD8+HLA-DR+/CD8+>70% would have, respectively, 11, 19 and 10 times greater chance of belonging to the HT group. Therefore, use of these phenotypic indicators as complementary laboratory methods for monitoring the clinical progression of chronic HTLV-1 infection is recommended.
- Subjects :
- Biomarkers
Chronic Disease
Disease Progression
HTLV-I Infections blood
Humans
Lymphocyte Count
Paraparesis, Tropical Spastic blood
Paraparesis, Tropical Spastic immunology
Phenotype
Predictive Value of Tests
ROC Curve
Reproducibility of Results
B-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
HLA-DR Antigens immunology
HTLV-I Infections immunology
Subjects
Details
- Language :
- Portuguese
- ISSN :
- 0037-8682
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Publication Type :
- Academic Journal
- Accession number :
- 17486250
- Full Text :
- https://doi.org/10.1590/s0037-86822007000100006