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Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice.
- Source :
-
Virology [Virology] 2007 Sep 01; Vol. 365 (2), pp. 292-301. Date of Electronic Publication: 2007 May 03. - Publication Year :
- 2007
-
Abstract
- The major histocompatibility complex (MHC) class-I restricted epitope of Hantaan virus nucleocapsid protein (N) was identified using overlapping peptides and BALB/c mice. Using the MHC tetramer derived from the epitope, we found that the level of N-specific CD8(+) T cells increased to approximately 20% of all antigen-specific CD8(+) T cells in a mouse model of transient infection. However, N-specific CD8(+) T cells were undetectable in a mouse model of persistent infection, both in the persistently infected phase and in the convalescent phase. Levels of CD8(+) T cells producing interferon-gamma were weak in both the acute and convalescent phases in the persistently infected model. These results indicate that hantavirus strongly suppresses the production of N-specific CD8(+) T cells throughout the course of infection in persistently infected mice. Moreover, N-specific CD8(+) T cells were not effective in recovering persistently infected mice, despite the existence of abundant N antigen in vivo.
- Subjects :
- Animals
Epitope Mapping
Epitopes, T-Lymphocyte
Female
Interferon-gamma biosynthesis
Mice
Mice, Inbred BALB C
CD8-Positive T-Lymphocytes immunology
Capsid Proteins immunology
Hantaan virus immunology
Hemorrhagic Fever with Renal Syndrome immunology
T-Lymphocyte Subsets immunology
Viral Core Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0042-6822
- Volume :
- 365
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 17481691
- Full Text :
- https://doi.org/10.1016/j.virol.2007.02.039