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Altered macrophage differentiation and immune dysfunction in tumor development.
- Source :
-
The Journal of clinical investigation [J Clin Invest] 2007 May; Vol. 117 (5), pp. 1155-66. - Publication Year :
- 2007
-
Abstract
- Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which cause sustained myelopoiesis and the accumulation and functional differentiation of myelomonocytic cells, most of which are macrophages, at the tumor site. An important side effect of the accumulation and functional differentiation of these cells is that they can induce lymphocyte dysfunction. A complete understanding of the complex interplay between neoplastic and myelomonocytic cells might offer novel targets for therapeutic intervention aimed at depriving tumor cells of important growth support and enhancing the antitumor immune response.
- Subjects :
- Animals
Humans
Immune System Diseases prevention & control
Immune System Diseases therapy
Neoplasms therapy
Cell Differentiation immunology
Immune System Diseases immunology
Immune System Diseases pathology
Macrophages immunology
Macrophages pathology
Neoplasms immunology
Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-9738
- Volume :
- 117
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 17476345
- Full Text :
- https://doi.org/10.1172/JCI31422