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Substantial shared genetic influences on schizophrenia and event-related potentials.
- Source :
-
The American journal of psychiatry [Am J Psychiatry] 2007 May; Vol. 164 (5), pp. 804-12. - Publication Year :
- 2007
-
Abstract
- Objective: Several components of event-related potentials--P50 suppression, P300 amplitude and latency, and mismatch negativity--have been proposed as potential endophenotypes for schizophrenia on the basis of family studies. The present study used a twin design to estimate the extent of genetic overlap between these indices and the liability to schizophrenia.<br />Method: The authors measured mismatch negativity, P300, and P50 suppression in 16 monozygotic twin pairs concordant for schizophrenia, nine monozygotic twin pairs discordant for schizophrenia, and 78 healthy comparison twin pairs. The study design was based on a power calculation. Structural equation modeling was used to quantify the genetic and environmental contributions to the phenotypic covariance between schizophrenia and each of the event-related potential indices.<br />Results: Significant phenotypic correlation with schizophrenia was found for each of the event-related potential components. Genetic factors were the main source of the phenotypic correlations. P50 suppression had the greatest genetic correlation with schizophrenia, followed by P300 amplitude, P300 latency, and mismatch negativity.<br />Conclusions: All four event-related potential indices are potentially valid endophenotypes for schizophrenia, but P50 suppression and P300 amplitude show the closest genetic relationship to schizophrenia.
- Subjects :
- Acoustic Stimulation
Adult
Electroencephalography statistics & numerical data
Event-Related Potentials, P300 genetics
Evoked Potentials physiology
Family
Female
Genetic Predisposition to Disease genetics
Humans
Male
Middle Aged
Models, Genetic
Models, Statistical
Neural Inhibition physiology
Pedigree
Phenotype
Reaction Time physiology
Schizophrenia physiopathology
Social Environment
Twins, Monozygotic genetics
Diseases in Twins genetics
Evoked Potentials genetics
Schizophrenia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0002-953X
- Volume :
- 164
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 17475740
- Full Text :
- https://doi.org/10.1176/ajp.2007.164.5.804