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Post-mortem stability and redistribution of carbohydrate-deficient transferrin (CDT).
- Source :
-
Forensic science international [Forensic Sci Int] 2008 Jan 30; Vol. 174 (2-3), pp. 161-5. Date of Electronic Publication: 2007 May 01. - Publication Year :
- 2008
-
Abstract
- Post-mortem diagnosis of chronic alcohol abuse is a challenge for forensic experts due to the lack of pathognomonic morphological findings and often also inadequate background information. Objective methods demonstrating chronic excessive alcohol consumption would therefore be a useful tool for forensic pathologists. In clinical practice, several markers of chronic alcohol abuse have recently been introduced, among which carbohydrate-deficient transferrin (CDT) is the most accepted, but the use of these markers in autopsy has not yet been established. We examined post-mortem stability and possible post-mortem redistribution of CDT and compared two analytical methods, capillary zone electrophoresis and high-performance liquid chromatography. According to our results, CDT remains stable for an appreciable time after death. The results further indicate that CDT is not subject to major post-mortem redistribution.
Details
- Language :
- English
- ISSN :
- 1872-6283
- Volume :
- 174
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Forensic science international
- Publication Type :
- Academic Journal
- Accession number :
- 17475426
- Full Text :
- https://doi.org/10.1016/j.forsciint.2007.03.020