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Ro-associated Y RNAs in metazoans: evolution and diversification.
- Source :
-
Molecular biology and evolution [Mol Biol Evol] 2007 Aug; Vol. 24 (8), pp. 1678-89. Date of Electronic Publication: 2007 Apr 29. - Publication Year :
- 2007
-
Abstract
- The Y genes encode small noncoding RNAs whose functions remain elusive, whose numbers vary between species, and whose major property is to be bound by the Ro60 protein (or its ortholog in other species). To better understand the evolution of the Y gene family, we performed a homology search in 27 different genomes along with a structural search using Y RNA specific motifs. These searches confirmed that Y RNAs are well conserved in the animal kingdom and resulted in the detection of several new Y RNA genes, including the first Y RNAs in insects and a second Y RNA detected in Caenorhabditis elegans. Unexpectedly, Y5 genes were retrieved almost as frequently as Y1 and Y3 genes, and, consequently are not the result of a relatively recent apparition as is generally believed. Investigation of the organization of the Y genes demonstrated that the synteny was conserved among species. Interestingly, it revealed the presence of six putative "fossil" Y genes, all of which were Y4 and Y5 related. Sequence analysis led to inference of the ancestral sequences for all Y RNAs. In addition, the evolution of existing Y RNAs was deduced for many families, orders and classes. Moreover, a consensus sequence and secondary structure for each Y species was determined. Further evolutionary insight was obtained from the analysis of several thousand Y retropseudogenes among various species. Taken together, these results confirm the rich and diversified evolution history of Y RNAs.
- Subjects :
- Animals
Autoantigens classification
Autoantigens metabolism
Base Sequence
Conserved Sequence
Evolution, Molecular
Humans
Male
Molecular Sequence Data
Nucleic Acid Conformation
Phylogeny
RNA classification
Ribonucleoproteins classification
Ribonucleoproteins genetics
Sequence Homology, Nucleic Acid
Testis physiology
Autoantigens genetics
RNA genetics
RNA, Small Cytoplasmic genetics
Ribonucleoproteins metabolism
Vertebrates genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0737-4038
- Volume :
- 24
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Molecular biology and evolution
- Publication Type :
- Academic Journal
- Accession number :
- 17470436
- Full Text :
- https://doi.org/10.1093/molbev/msm084