Back to Search
Start Over
The 4C technique: the 'Rosetta stone' for genome biology in 3D?
- Source :
-
Current opinion in cell biology [Curr Opin Cell Biol] 2007 Jun; Vol. 19 (3), pp. 321-5. Date of Electronic Publication: 2007 Apr 26. - Publication Year :
- 2007
-
Abstract
- Despite considerable efforts, the spatial link between the nuclear architecture and the genome remains enigmatic. The 4C method, independently innovated in four different laboratories, might in combination with other methods change that. As this method is based on the unbiased identification of sequences interacting with specific baits, there are unique opportunities for unravelling the secrets of how the genome functions in 3D.
- Subjects :
- Animals
Base Sequence
DNA Primers
Forecasting
Genome, Human
Humans
Models, Biological
Molecular Sequence Data
Nucleic Acid Amplification Techniques
Nucleic Acid Conformation
Biology
Chromosome Mapping
DNA, Circular
Genome
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Sequence Analysis, DNA
Subjects
Details
- Language :
- English
- ISSN :
- 0955-0674
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current opinion in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 17466501
- Full Text :
- https://doi.org/10.1016/j.ceb.2007.04.008