Intraocular use of rituximab.

Authors :: Kitzmann AS
Pulido JS
Mohney BG
Baratz KH
Grube T
Marler RJ
Donaldson MJ
O'Neill BP
Johnston PB
Johnson KM
Dixon LE
Salomao DR
Cameron JD
Source :: Eye (London, England) [Eye (Lond)] 2007 Dec; Vol. 21 (12), pp. 1524-7. Date of Electronic Publication: 2007 Apr 20.
Publication Year :: 2007
Abstract: Purpose: To evaluate the toxicity of 1 mg of intraocular rituximab and to present a small case-series of patients treated with intravitreal rituximab.<br />Methods: Rituximab (1 mg/0.1 ml) was injected in the vitreous of one eye of three Dutch-belted rabbits. Two animals were injected with balanced salt solution as controls. At 1 month the rabbits were killed and the eyes examined by light microscopy. Three patients (five eyes) with intraocular lymphoma were also treated with a 1 mg injection of rituximab.<br />Results: The treated rabbit eyes and the control eyes showed no light microscopic evidence of ocular toxicity at 1 month following injection. The five human eyes of three patients have shown no evidence of intraocular toxicity with a median follow-up time of 3.6 months (range 2.0-6.4 months). One patient received a total of four injections in the right eye and three injections in the left eye.<br />Conclusion: Intravitreal rituximab at a dose of 1 mg does not appear to cause toxicity in rabbit eyes and in the five eyes of three patients.