CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy.

Authors :: Buyse GM
Goemans N
Henricson E
Jara A
van den Hauwe M
Leshner R
Florence JM
Mayhew JE
Escolar DM
Source :: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2007 Nov; Vol. 11 (6), pp. 337-40. Date of Electronic Publication: 2007 Apr 24.
Publication Year :: 2007
Abstract: The authors report a pilot open-label two-center therapeutic trial of oxatomide in 14 steroid-naive DMD boys aged 5-10 years. Comparison of linear evolutions between 3 months medication-free lead-in periods and 6 months treatment periods showed no significant differences in quantitative (QMT) and manual (MMT) measurements of muscle strength and timed functional tests. A modest mitigation of strength deterioration over time cannot be excluded.

Subjects :: Child
Child, Preschool
Female
Follow-Up Studies
Humans
Linear Models
Male
Muscle Strength drug effects
Pilot Projects
Time Factors
Treatment Outcome
Histamine H1 Antagonists therapeutic use
Muscular Dystrophy, Duchenne drug therapy
Piperazines therapeutic use

Language :: English
ISSN :: 1090-3798
Volume :: 11
Issue :: 6
Database :: MEDLINE
Journal :: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Publication Type :: Academic Journal
Accession number :: 17459739
Full Text :: https://doi.org/10.1016/j.ejpn.2007.02.009