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Mutagenic evaluation and chemical investigation of Byrsonima intermedia A. Juss. leaf extracts.

Authors :
Sannomiya M
Cardoso CR
Figueiredo ME
Rodrigues CM
dos Santos LC
dos Santos FV
Serpeloni JM
Cólus IM
Vilegas W
Varanda EA
Source :
Journal of ethnopharmacology [J Ethnopharmacol] 2007 Jun 13; Vol. 112 (2), pp. 319-26. Date of Electronic Publication: 2007 Mar 14.
Publication Year :
2007

Abstract

Byrsonima intermedia is a native species of the cerrado formation (tropical American savannah). In Brazil, this plant has been used for the treatment of fever, in ulcers, as a diuretic, as antiasthmatics and in skin infections. Members of the genus Byrsonima (Malpighiaceae) are employed not only in the folk medicine but also as food to make juice, jellies and liquor. The aim of this work was to evaluate the mutagenic effects of Byrsonima intermedia, common name 'murici'. Phytochemical analysis of methanol extract furnished (+)-catechin, (-)-epicatechin, quercetin-3-O-beta-d-galactopyranoside, methyl gallate, gallic acid, quercetin-3-O-alpha-l-arabinopyranoside, amentoflavone, quercetin, quercetin-3-O-(2''-O-galloyl)-beta-galactopyranoside and quercetin-3-O-(2''-O-galloyl)-alpha-arabinopyranoside. Methanol, hydromethanol and chloroform extracts were evaluated in mutagenic assay with Salmonella typhimurium (Ames test) and mice (Micronucleus test). The methanolic extract presented signs of mutagenic activity for the strains TA98 and TA100 in the Ames assay. Mutagenicity was not observed in vivo.

Details

Language :
English
ISSN :
0378-8741
Volume :
112
Issue :
2
Database :
MEDLINE
Journal :
Journal of ethnopharmacology
Publication Type :
Academic Journal
Accession number :
17459621
Full Text :
https://doi.org/10.1016/j.jep.2007.03.014