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Mutagenic evaluation and chemical investigation of Byrsonima intermedia A. Juss. leaf extracts.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2007 Jun 13; Vol. 112 (2), pp. 319-26. Date of Electronic Publication: 2007 Mar 14. - Publication Year :
- 2007
-
Abstract
- Byrsonima intermedia is a native species of the cerrado formation (tropical American savannah). In Brazil, this plant has been used for the treatment of fever, in ulcers, as a diuretic, as antiasthmatics and in skin infections. Members of the genus Byrsonima (Malpighiaceae) are employed not only in the folk medicine but also as food to make juice, jellies and liquor. The aim of this work was to evaluate the mutagenic effects of Byrsonima intermedia, common name 'murici'. Phytochemical analysis of methanol extract furnished (+)-catechin, (-)-epicatechin, quercetin-3-O-beta-d-galactopyranoside, methyl gallate, gallic acid, quercetin-3-O-alpha-l-arabinopyranoside, amentoflavone, quercetin, quercetin-3-O-(2''-O-galloyl)-beta-galactopyranoside and quercetin-3-O-(2''-O-galloyl)-alpha-arabinopyranoside. Methanol, hydromethanol and chloroform extracts were evaluated in mutagenic assay with Salmonella typhimurium (Ames test) and mice (Micronucleus test). The methanolic extract presented signs of mutagenic activity for the strains TA98 and TA100 in the Ames assay. Mutagenicity was not observed in vivo.
- Subjects :
- Animals
Chloroform
Cyclophosphamide toxicity
Methanol
Mice
Micronucleus Tests
Plant Extracts toxicity
Plant Leaves chemistry
Rats
Reticulocytes drug effects
Reticulocytes ultrastructure
Salmonella typhimurium drug effects
Salmonella typhimurium genetics
Solvents
Mutagens toxicity
Plants chemistry
Plants toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0378-8741
- Volume :
- 112
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 17459621
- Full Text :
- https://doi.org/10.1016/j.jep.2007.03.014