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Maintenance of HIV-specific central and effector memory CD4 and CD8 T cells requires antigen persistence.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2007 Apr; Vol. 23 (4), pp. 549-53. - Publication Year :
- 2007
-
Abstract
- The HIV-specific central and effector CD4 and CD8 memory T cell populations disappear from the peripheral blood of infected individuals under highly active antiretroviral therapy (HAART) with a mean half-life of 6.0 and 7.7 months, respectively. By contrast, cytomegalovirus (CMV)-specific responses are stable or increase. The striking quantitative differences between T cell memory to two persistent viral infections are instructive as to how antigen dosage contributes to the maintenance of antigen-specific memory T cell responses in humans.
- Subjects :
- Antiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes virology
CD8-Positive T-Lymphocytes virology
Humans
Kinetics
T-Lymphocyte Subsets
T-Lymphocytes, Cytotoxic virology
Viral Load classification
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Cytomegalovirus immunology
HIV Infections immunology
HIV-1 immunology
Immunologic Memory immunology
T-Lymphocytes, Cytotoxic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0889-2229
- Volume :
- 23
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 17451343
- Full Text :
- https://doi.org/10.1089/aid.2006.0234