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Lateral hypothalamic 'command neurons' with axonal projections to regions involved in both feeding and thermogenesis.
- Source :
-
The European journal of neuroscience [Eur J Neurosci] 2007 Apr; Vol. 25 (8), pp. 2404-12. - Publication Year :
- 2007
-
Abstract
- The concept of 'command neurons', whereby single neurons mediate complex and complementary motor functions to generate a stereotyped behaviour, is well developed in invertebrate physiology. The term has also been adopted more recently to explain the neural basis of 'fight or flight'. In this study we have investigated the possibility that single lateral hypothalamic neurons have the necessary neuroanatomical connections to coordinate two complementary limbs of body weight control, feeding and thermogenesis, thereby acting as 'command neurons'. The transynaptic retrograde transport of pseudorabies virus (Bartha) from a thermogenic endpoint in the brown adipose tissue of rats has been used in conjunction with other neuronal tracers, introduced into putative CNS feeding centres, to assess the potential for the involvement of command neurons in coordinating these processes. In discrete regions of the lateral hypothalamus, neurons have been identified which have the necessary complement of orexigenic peptides and collateral branching axons to both putative feeding sites and thermogenic sites in brown fat to qualify as candidate central command neurons controlling body weight.
- Subjects :
- Adipose Tissue, Brown anatomy & histology
Animals
Fluorescent Dyes metabolism
Herpesvirus 1, Suid metabolism
Hypothalamic Hormones metabolism
Intracellular Signaling Peptides and Proteins metabolism
Male
Medulla Oblongata cytology
Medulla Oblongata metabolism
Melanins metabolism
Nerve Tissue Proteins metabolism
Neurons cytology
Neuropeptides metabolism
Orexins
Pituitary Hormones metabolism
Rats
Rats, Sprague-Dawley
Staining and Labeling
Brain Mapping
Feeding Behavior physiology
Hypothalamic Area, Lateral cytology
Neural Pathways anatomy & histology
Neural Pathways physiology
Neurons metabolism
Thermogenesis physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0953-816X
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The European journal of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 17445237
- Full Text :
- https://doi.org/10.1111/j.1460-9568.2007.05429.x