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Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure.
- Source :
-
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2007; Vol. 114 (6), pp. 841-3. Date of Electronic Publication: 2007 Apr 13. - Publication Year :
- 2007
-
Abstract
- Despite recent intensive investigations, physiological and pathological role of semicarbazide-sensitive amine oxidase (SSAO) is far from clear. In this study, serum SSAO activity was determined, radiochemically, in various groups of uremic patients: haemodialysed (HD), peritoneally dialysed (PD) and those receiving conservative treatment but still not dialysed (ND), as well as in controls. Reduced enzyme activity was found in HD uremic patients before and after dialysis treatment, compared to controls (5260 +/- 862 and 6011 +/- 958 pmol/h/ml vs. 8601 +/- 283 pmol/h/ml, p < 0.01 and p < 0.05, respectively). The activity was slightly lower in PD, and normal in ND patients. In HD patients SSAO activity was also determined by an assay based on the formation of hydrogen peroxide, and was found to be elevated compared to controls (2384 +/- 323 pmol/h/ml vs. 1437 +/- 72 pmol/h/ml, p < 0.05). The elevated serum SSAO activity measured through the detection of the enzyme-generated hydrogen peroxide in HD patients might indicate its contribution to the accelerated atherosclerotic disease observed in uremia.
- Subjects :
- Amine Oxidase (Copper-Containing) analysis
Biomarkers analysis
Biomarkers blood
Dialysis
Humans
Kidney physiopathology
Kidney Failure, Chronic physiopathology
Up-Regulation physiology
Uremia blood
Uremia enzymology
Uremia physiopathology
Amine Oxidase (Copper-Containing) blood
Kidney enzymology
Kidney Failure, Chronic blood
Kidney Failure, Chronic enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0300-9564
- Volume :
- 114
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission (Vienna, Austria : 1996)
- Publication Type :
- Academic Journal
- Accession number :
- 17431736
- Full Text :
- https://doi.org/10.1007/s00702-007-0698-4