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Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jun 01; Vol. 17 (11), pp. 3006-9. Date of Electronic Publication: 2007 Mar 21. - Publication Year :
- 2007
-
Abstract
- Selective bradykinin (BK) B(1) receptor antagonists have been shown to be antinociceptive in animal models and could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure-activity relationships of the biphenyl moiety of the lead compound 1 provided a potent new structural class of BK B(1) receptor antagonists.
- Subjects :
- Analgesics chemical synthesis
Analgesics pharmacology
Animals
Animals, Genetically Modified
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Cyclohexanes chemical synthesis
Cyclohexanes pharmacology
Humans
Hydrocarbons, Fluorinated chemical synthesis
Hydrocarbons, Fluorinated pharmacology
Pyridines chemical synthesis
Pyridines pharmacology
Rats
Receptor, Bradykinin B1 genetics
Structure-Activity Relationship
Analgesics chemistry
Anti-Inflammatory Agents, Non-Steroidal chemistry
Bradykinin B1 Receptor Antagonists
Cyclohexanes chemistry
Hydrocarbons, Fluorinated chemistry
Pyridines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17428657
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.03.059