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[Gadolinium-loaded nanoparticle as a novel molecular imaging contrast agent for magnetic resonance imaging].
- Source :
-
Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2007 Jan 23; Vol. 87 (4), pp. 240-3. - Publication Year :
- 2007
-
Abstract
- Objective: To synthesize a novel gadolinium-loaded nanoparticle as a molecular imaging contrast agent for magnetic resonance imaging.<br />Methods: Gadolinium ion was incorporated within a silica nanoparticle. The size of this nanosized particle was determined by using transmission electron microscope. The spin-echo (SE) images of nine nanoparticle dilutions in vitro were obtained from a 1.5 T clinical scanner, compared with gadolinium diethylene triaminepenta acetate (Gd-DTPA). In vivo distribution of nanoparticle in Balb/c nude mice and Balb/c nude mice with nasopharyngeal carcinoma (NPC) xenografted CNE-2 tumors was studied at MR imaging, 30 sec, 5 min, 30 min, 1 h, 2 h, 4 h, and 24 h after intravenous administration.<br />Results: The gadolinium-loaded nanoparticle was short rod-shaped, and approximately 30 to 40 nm in diameter. The value of longitudinal relaxativity (r(1)) of gadolinium nanoparticle was much higher than that of Gd-DTPA. Thirty minutes after injection the gadolinium nanoparticle, the signal intensities of liver, kidney and xenografted tumor increased from 226 +/- 10, 283 +/- 7 and 195 +/- 5 to 352 +/- 12, 328 +/- 10 and 245 +/- 7, respectively. The dynamic MRI scanning showed that gadolinium nanoparticles were mainly distributed in liver after intravenous administration. Strong enhancement was also detected in CNE-2 xenografted tumors.<br />Conclusion: A new gadolinium-loaded nanoparticle with high relaxativity was synthesized successfully, and might serve as a carrier for magnetic resonance molecular imaging.
- Subjects :
- Animals
Cell Line, Tumor
Contrast Media chemistry
Female
Gadolinium DTPA chemistry
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Microscopy, Electron, Transmission
Nanostructures chemistry
Nanostructures ultrastructure
Nasopharyngeal Neoplasms metabolism
Nasopharyngeal Neoplasms pathology
Neoplasm Transplantation
Neoplasms, Experimental metabolism
Neoplasms, Experimental pathology
Particle Size
Transplantation, Heterologous
Contrast Media pharmacokinetics
Gadolinium DTPA pharmacokinetics
Magnetic Resonance Spectroscopy methods
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0376-2491
- Volume :
- 87
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhonghua yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 17425867