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Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2007 Mar; Vol. 30 (3), pp. 270-4. - Publication Year :
- 2007
-
Abstract
- Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marine-derived actinomycete Z(2)039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 microM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.
- Subjects :
- Alkaloids chemistry
Alkaloids pharmacology
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Carbazoles chemistry
Carbazoles pharmacology
Humans
Indoles chemistry
Indoles isolation & purification
Indoles pharmacology
K562 Cells
Magnetic Resonance Spectroscopy
Water Microbiology
Actinobacteria metabolism
Alkaloids isolation & purification
Antineoplastic Agents, Phytogenic isolation & purification
Apoptosis drug effects
Carbazoles isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0253-6269
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 17424930
- Full Text :
- https://doi.org/10.1007/BF02977605