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Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2008 Sep; Vol. 29 (9), pp. 1296-307. Date of Electronic Publication: 2007 Apr 08. - Publication Year :
- 2008
-
Abstract
- The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not A beta deposition staging. The total number of spinophilin-immunoreactive puncta in CA1 field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA1 field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.
- Subjects :
- Aged
Biomarkers metabolism
Disease Progression
Female
Humans
Immunohistochemistry
Male
Nerve Net metabolism
Nerve Net pathology
Tissue Distribution
Alzheimer Disease metabolism
Alzheimer Disease pathology
Dendritic Spines metabolism
Dendritic Spines pathology
Hippocampus metabolism
Hippocampus pathology
Microfilament Proteins metabolism
Nerve Tissue Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 29
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 17420070
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2007.03.007