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[The peculiarities of the clinical picture and the effectiveness of antiviral therapy of chronic hepatitis related to alcohol consumption plus hepatitis C virus effect].
- Source :
-
Klinicheskaia meditsina [Klin Med (Mosk)] 2007; Vol. 85 (1), pp. 47-51. - Publication Year :
- 2007
-
Abstract
- The purpose of this study was to describe the features of chronic hepatitis when the damaging action of alcohol was combined with that of hepatitis C virus, and to investigate the effectiveness of combined antiviral therapy in this category of patients. The study showed that patients with chronic hepatitis of combined ethiology (alcohol plus HCV) had higher biochemical and histological activity of the disease, as well as certain histological features. The effectiveness of combined antiviral therapy was comparable in both alcohol consumers and non-consumers with hepatitis C, which makes it possible to consider the former category as candidates for antiviral treatment under the condition that they follow doctor's recommendations and abstain from alcohol consumption.
- Subjects :
- Adult
Biopsy
Drug Therapy, Combination
Female
Follow-Up Studies
Hepacivirus genetics
Hepacivirus immunology
Hepatitis C Antibodies analysis
Hepatitis C, Chronic complications
Hepatitis C, Chronic diagnosis
Hepatitis, Alcoholic complications
Hepatitis, Alcoholic diagnosis
Humans
Interferon alpha-2
Liver diagnostic imaging
Liver pathology
Male
Middle Aged
RNA, Viral analysis
Recombinant Proteins
Severity of Illness Index
Ultrasonography
Antiviral Agents therapeutic use
Hepatitis C, Chronic drug therapy
Hepatitis, Alcoholic drug therapy
Interferon-alpha therapeutic use
Ribavirin therapeutic use
Subjects
Details
- Language :
- Russian
- ISSN :
- 0023-2149
- Volume :
- 85
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Klinicheskaia meditsina
- Publication Type :
- Academic Journal
- Accession number :
- 17419356