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Novel aminoethylbiphenyls as 5-HT7 receptor ligands.

Authors :
Paillet-Loilier M
Fabis F
Lepailleur A
Bureau R
Butt-Gueulle S
Dauphin F
Lesnard A
Delarue C
Vaudry H
Rault S
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jun 01; Vol. 17 (11), pp. 3018-22. Date of Electronic Publication: 2007 Mar 23.
Publication Year :
2007

Abstract

The synthesis of a series of aminoethylbiphenyls as novel 5-HT(7) receptor ligands is described. The novel derivatives exhibit high affinity for the 5-HT(7) receptor with selectivity toward 5-HT(1A) receptor.

Details

Language :
English
ISSN :
0960-894X
Volume :
17
Issue :
11
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
17419056
Full Text :
https://doi.org/10.1016/j.bmcl.2007.03.054