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Metal carbonyls as pharmaceuticals? [Ru(CO)3Cl(glycinate)], a CO-releasing molecule with an extensive aqueous solution chemistry.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2007 Apr 21 (15), pp. 1500-8. Date of Electronic Publication: 2007 Mar 08. - Publication Year :
- 2007
-
Abstract
- The pharmacologically active [Ru(CO)(3)Cl(glycinate)] is shown to be in equilibrium with [Ru(CO)(2)(CO(2)H)Cl(glycinate)](-) (isomers) at around pH 3.1 which then at physiological pH reacts with more base to give [Ru(CO)(2)(CO(2))Cl(glycinate)](2-) (isomers) or [Ru(CO)(2)(CO(2)H)(OH)(glycinate)](-) (isomers). The ease with which [Ru(CO)(3)Cl(glycinate)] reacts with hydroxide results in it producing a solution in water with a pH of around 2 to 2.5 depending on concentration and making its solutions more acidic than those of acetic acid at comparable concentrations. Acidification of [Ru(CO)(3)Cl(glycinate)] with HCl gives [Ru(CO)(3)Cl(2)(NH(2)CH(2)CO(2)H)]. The crystal structures of [Ru(CO)(3)Cl(glycinate)] and [Ru(CO)(3)Cl(2)(NH(2)CH(2)CO(2)Me)] are reported.
- Subjects :
- Crystallography, X-Ray
Glycine chemical synthesis
Glycine chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Organometallic Compounds chemistry
Solutions
Spectrophotometry, Infrared
Water chemistry
Carbon Monoxide chemistry
Glycine analogs & derivatives
Organometallic Compounds chemical synthesis
Ruthenium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9226
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 17404651
- Full Text :
- https://doi.org/10.1039/b613629j