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Anemia in patients with Wegener's granulomatosis.
- Source :
-
Clinical nephrology [Clin Nephrol] 2007 Mar; Vol. 67 (3), pp. 149-56. - Publication Year :
- 2007
-
Abstract
- Aims: Anemia is commonly observed among patients with chronic kidney disease (CKD). No such information is available for patients with a history of systemic vasculitis.<br />Methods: We examined the prevalence of anemia, the response to therapy with erythropoiesis-stimulating agents (ESA), and the association of anemia with the kidney function in clinically stable patients with Wegener's granulomatosis in a retrospective, single-center study.<br />Results: The mean hemoglobin concentration of 36 patients (mean age: 58 years; 15 female, 21 male; mean duration of disease: 4.6 years) was 13.0+/-2.1 g/dl, and the mean estimated glomerular filtration rate (eGFR) was 41+/-21 ml/min/1.73 m(2). 14 of 36 patients (38.8%) presented with anemia (hemoglobin concentration < 12 g/dl in women, < 13 g/dl in men, or ESA therapy). In patients with a CKD Stage 3 or 4, anemia was present about twice as much as compared to the Third National Health and Nutrition Examination Survey (NHANES III) population. The hemoglobin concentration, however, was not associated with a change of kidney function (p = 0.1578).<br />Conclusions: We found a higher prevalence of anemia in patients with Wegener's granulomatosis, as compared to the NHANES III population. The hemoglobin concentrations showed no association with changes of kidney function.
- Subjects :
- Anemia drug therapy
Anemia etiology
Creatinine blood
Darbepoetin alfa
Drug Therapy, Combination
Erythropoietin analogs & derivatives
Erythropoietin therapeutic use
Female
Glomerular Filtration Rate physiology
Granulomatosis with Polyangiitis blood
Granulomatosis with Polyangiitis physiopathology
Hematinics therapeutic use
Hemoglobins metabolism
Humans
Kidney Failure, Chronic blood
Kidney Failure, Chronic complications
Kidney Failure, Chronic physiopathology
Male
Middle Aged
Outpatients
Prevalence
Prognosis
Recombinant Proteins
Retrospective Studies
Severity of Illness Index
Anemia epidemiology
Granulomatosis with Polyangiitis complications
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0430
- Volume :
- 67
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 17390739
- Full Text :
- https://doi.org/10.5414/cnp67149