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[Systemic immunosuppressives after penetrating keratoplasty].
- Source :
-
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft [Ophthalmologe] 2007 May; Vol. 104 (5), pp. 373-80. - Publication Year :
- 2007
-
Abstract
- Immunologic rejection is the main cause of corneal graft failure. If corneal transplantation is performed in a high-risk situation without the use of systemic immunosuppression, corneal graft failure has to be expected in over 50% of patients within the first postoperative year. The clonal expansion of graft-specific lymphocytes occurs in lymphoid tissues. As topical steroids do not reach the secondary lymphoid organs, and even systemic steroids do not interfere sufficiently with the clonal expansion of activated T cells, it is essential to administer systemic immunosuppressives in order to achieve clear graft survival. As corneal transplantation is not a life-saving procedure, the profile of side-effects is a central issue when choosing an immunosuppressive medication.
- Subjects :
- Administration, Oral
Administration, Topical
Animals
Humans
Immunosuppressive Agents adverse effects
Infusions, Intravenous
Ophthalmic Solutions
Corneal Opacity prevention & control
Graft Rejection prevention & control
Immunosuppressive Agents administration & dosage
Keratoplasty, Penetrating
Postoperative Complications prevention & control
Subjects
Details
- Language :
- German
- ISSN :
- 0941-293X
- Volume :
- 104
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
- Publication Type :
- Academic Journal
- Accession number :
- 17387480
- Full Text :
- https://doi.org/10.1007/s00347-007-1517-x