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[Utility of FDG-PET for early evaluation of efficiency of imatinib mesylate (Glivec) in the treatment of gastrointestinal stromal tumors].
[Utility of FDG-PET for early evaluation of efficiency of imatinib mesylate (Glivec) in the treatment of gastrointestinal stromal tumors].
- Source :
-
Revista espanola de medicina nuclear [Rev Esp Med Nucl] 2007 Mar-Apr; Vol. 26 (2), pp. 100-2. - Publication Year :
- 2007
-
Abstract
- The management of gastrointestinal stromal tumors, usually defined as c-KIT-positive mesenchymal neoplasias, has evolved very rapidly in the last five years. Imatinib mesylate (Glivec(R)) is the standard treatment in unresectable or metastatic gastrointestinal stromal tumors. Imatinib should be given until development of intolerance or progressive disease. It is not uncommon for gastrointestinal stromal tumors to become larger during the early post-treatment phase and conventional response to treatment criteria in solid tumors have a limited value for evaluation the efficiency of imatinib in this period. FDG-PET has proven to be highly sensitive in detecting early response tumor. A 53-year old woman was diagnosed of relapsed gastrointestinal stromal tumor 18 months after adyuvant imatinib mesylate finished. Imatinib was started and 72 hours later the tumor showed a decrease of fluorodeoxyglucose F18 uptake on positron emission tomography scan.
- Subjects :
- Antineoplastic Agents pharmacokinetics
Benzamides
Combined Modality Therapy
Disease Progression
Female
Gastrointestinal Stromal Tumors drug therapy
Gastrointestinal Stromal Tumors surgery
Humans
Imatinib Mesylate
Middle Aged
Palliative Care
Pelvic Neoplasms drug therapy
Pelvic Neoplasms surgery
Peritoneal Neoplasms drug therapy
Peritoneal Neoplasms surgery
Piperazines pharmacokinetics
Pyrimidines pharmacokinetics
Antineoplastic Agents therapeutic use
Fluorodeoxyglucose F18
Gastrointestinal Stromal Tumors diagnostic imaging
Gastrointestinal Stromal Tumors secondary
Pelvic Neoplasms diagnostic imaging
Peritoneal Neoplasms diagnostic imaging
Peritoneal Neoplasms secondary
Piperazines therapeutic use
Positron-Emission Tomography
Pyrimidines therapeutic use
Radiopharmaceuticals
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0212-6982
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Revista espanola de medicina nuclear
- Publication Type :
- Academic Journal
- Accession number :
- 17386236
- Full Text :
- https://doi.org/10.1157/13099949