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[Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer].
- Source :
-
Journal de chirurgie [J Chir (Paris)] 2007 Jan-Feb; Vol. 144 (1), pp. 13-8. - Publication Year :
- 2007
-
Abstract
- Tumors arising sporadically represent 70-80% of colorectal cancer (CRC). The two best defined forms of inherited CRC-familial multiple polyposis (FMP) and Hereditary Non-Polyposis Colon Cancer (HNPCC) account respectively for<1% and 2-3% of CRC. These rare genetic syndromes (FMP, HNPCC, Peutz-Jeghers Syndrome) are caused by major predisposing gene mutations (APC gene, MMR gene, BMPR1A. SMAD4,...) and local environmental factors play only a minor role. In the sporadic forms of CRC, 25% have significant genetic predisposition probably related to alleles with weak penetration (APC*I1307K, TGFbR1*6Ala...) and are more strongly affected by environmental factors.
- Subjects :
- Adenomatous Polyposis Coli genetics
Colorectal Neoplasms, Hereditary Nonpolyposis genetics
Environment
Genes, Tumor Suppressor
Humans
Mutation genetics
Penetrance
Peutz-Jeghers Syndrome genetics
Colonic Neoplasms genetics
Genetic Predisposition to Disease genetics
Rectal Neoplasms genetics
Subjects
Details
- Language :
- French
- ISSN :
- 0021-7697
- Volume :
- 144
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal de chirurgie
- Publication Type :
- Academic Journal
- Accession number :
- 17369756
- Full Text :
- https://doi.org/10.1016/s0021-7697(07)89450-6