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Unravelling the complexity of T cell abnormalities in common variable immunodeficiency.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2007 Mar 15; Vol. 178 (6), pp. 3932-43. - Publication Year :
- 2007
-
Abstract
- We investigated several phenotypic and functional parameters of T cell-mediated immunity in a large series of common variable immunodeficiency (CVID) patients. We demonstrated that the vast majority of CVID patients presented multiple T cell abnormalities intimately related among them, the severity of which was reflected in a parallel loss of CD4+ naive T cells. A strong correlation between the number of CD4+ naive T cells and clinical features was observed, supporting the subgrouping of patients according to their number of naive CD4+ T lymphocytes. A reduced thymic output and disrupted CD4+ and CD8+ TCR repertoires paralleled the contraction of CD4+ naive T cell pools. The evaluation of activation markers and cytokine production indicated a strong T cell activation that was significantly related to the increased levels of T cell turnover and apoptosis. Finally, discrete genetic profiles could be demonstrated in groups of patients showing extremely diverse T cell subset composition and function. Naive CD4+ T cell levels were significantly associated with the switched memory B cell-based classification, although the concordance between the respective subgroups did not exceed 58.8%. In conclusion, our data highlight the key role played by the T cell compartment in the pathogenesis of CVID, pointing to the need to consider this aspect for classification of this disease.
- Subjects :
- Adolescent
Adult
Aged
Apoptosis immunology
B-Lymphocytes pathology
CD4-Positive T-Lymphocytes pathology
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes pathology
Common Variable Immunodeficiency classification
Common Variable Immunodeficiency pathology
Common Variable Immunodeficiency physiopathology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Retrospective Studies
Thymus Gland pathology
Thymus Gland physiopathology
B-Lymphocytes immunology
CD4-Positive T-Lymphocytes immunology
Common Variable Immunodeficiency immunology
Immunoglobulin Class Switching immunology
Immunologic Memory
Thymus Gland immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 178
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 17339494
- Full Text :
- https://doi.org/10.4049/jimmunol.178.6.3932