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Case-control study between extrapleural pneumonectomy and radical pleurectomy/decortication for pathological N2 malignant pleural mesothelioma.
- Source :
-
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery [Eur J Cardiothorac Surg] 2007 May; Vol. 31 (5), pp. 765-70; discussion 770-1. Date of Electronic Publication: 2007 Mar 06. - Publication Year :
- 2007
-
Abstract
- Objective: To compare the outcomes of extrapleural pneumonectomy (EPP) and radical pleurectomy/decortication (P/D) for N2 malignant pleural mesothelioma (MM).<br />Patients and Methods: In a retrospective case-control study we analysed the results of the 57 patients [49 male and 8 female, median age 59 (range 14-70) years] who underwent radical surgery for MM found to have pathological N2 disease over a 7-year-period. EPP was performed on 45 and P/D on 12 patients. Prognostic factors, postoperative course, pathological data and postoperative survival were analysed.<br />Results: Those in the P/D group were significantly older (median age 62 vs 58 years, p=0.03) than in the EPP group. There was no difference in postoperative hospital stay (p=0.1) nor T stage (p=0.7) between the groups. There were no significant differences in the proportion of patients undergoing some adjuvant therapy in each group (p=0.2). Mean survival from diagnosis was 15 months in the EPP group and 16 months for those who underwent P/D (p=0.4).<br />Conclusions: Preservation of the lung during radical surgery for N2 MM does not compromise survival even in an older group population. We therefore now have ceased to perform EPP in cases of N2 disease and we make every effort to accurately stage patients with mediastinoscopy to identify them.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Case-Control Studies
Combined Modality Therapy methods
Female
Humans
Kaplan-Meier Estimate
Length of Stay
Male
Mesothelioma mortality
Mesothelioma pathology
Mesothelioma therapy
Middle Aged
Pleural Neoplasms mortality
Pleural Neoplasms pathology
Pleural Neoplasms therapy
Postoperative Period
Retrospective Studies
Treatment Outcome
Mesothelioma surgery
Pleura surgery
Pleural Neoplasms surgery
Pneumonectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1010-7940
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 17337201
- Full Text :
- https://doi.org/10.1016/j.ejcts.2007.01.064