Back to Search Start Over

Relation of ultrasound morphologic characteristics of central pulmonary artery thromboemboli to their ex vivo lysibility.

Authors :
Podbregar M
Gabrscek L
Pakiz M
Blinc A
Sabović M
Kralj E
Source :
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography [J Am Soc Echocardiogr] 2007 Mar; Vol. 20 (3), pp. 276-80.
Publication Year :
2007

Abstract

Background: Ultrasound morphology of massive central pulmonary artery thromboemboli (TE) is an independent predictor of 30-day mortality. The aim of this study was to asses ex vivo lysibility of morphologically different TE.<br />Methods: Forty-five central pulmonary artery TE, collected at autopsies, were divided into hypoechoic (group A) and hyperechoic (group B) categories. TE were lysed with alteplase in a perfusing system simulating pulmonary circulation for 1 hour.<br />Results: The grey scale mean of thrombi in group B was higher compared with group A (64 +/- 7 vs. 38 +/- 7, respectively, P < .01). Spontaneous lysis in group A did not differ compared with group B (2.2% +/- 0.5% vs. 2.1% +/- 0.4%, P = .4). After incubation with alteplase, the weight of TE was reduced more in group A than in group B (16% +/- 2% vs. 11% +/- 2%, P < .001). The grey scale mean negatively correlated with the percentage of TE weight reduction (0.768) (P < .001).<br />Conclusion: Ultrasound morphology of TE from central pulmonary arteries correlates significantly with ex vivo lysibility. Hypoechoic TE are more susceptible to thrombolysis than hyperechoic TE.

Details

Language :
English
ISSN :
1097-6795
Volume :
20
Issue :
3
Database :
MEDLINE
Journal :
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Publication Type :
Academic Journal
Accession number :
17336754
Full Text :
https://doi.org/10.1016/j.echo.2006.08.033