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[Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation].
- Source :
-
Nihon eiseigaku zasshi. Japanese journal of hygiene [Nihon Eiseigaku Zasshi] 2007 Jan; Vol. 62 (1), pp. 3-8. - Publication Year :
- 2007
-
Abstract
- We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.
Details
- Language :
- Japanese
- ISSN :
- 0021-5082
- Volume :
- 62
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nihon eiseigaku zasshi. Japanese journal of hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 17334087
- Full Text :
- https://doi.org/10.1265/jjh.62.3