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Oral involvement in chronic graft versus host disease: a prospective study of 19 Brazilian patients.
- Source :
-
General dentistry [Gen Dent] 2007 Jan-Feb; Vol. 55 (1), pp. 48-51. - Publication Year :
- 2007
-
Abstract
- Chronic graft versus host disease (cGVHD) is the most common late complication of allogeneic bone marrow transplantation. The oral cavity is the most common site of cGVHD involvement. This study sought to investigate the incidence of oral cGVHD, as well as the disease's impact on a patient's quality of life and the kind of lesions that resulted. Nineteen patients with cGVHD received a medical and dental evaluation; 18 (94.7%) had oral lesions. Nine patients (47.3%) demonstrated xerostomia and 6 (35.2%) demonstrated dysphagia. Six patients (35.2%) had a lichenoid clinical form of cGVHD in the oral cavity, 6 (35.2%) had an atrophic-ulcerative clinical form, 3 (17.6%) had a hyperceratotic clinical form, and 2 (10.5%) had mixed forms. The results demonstrated predominance of lichenoid and ulcerative-atrophic forms with similar incidence of these lesions. No factor that could contribute to the severity of cGVHD oral lesions was found.
- Subjects :
- Adult
Brazil
Chronic Disease
Deglutition Disorders etiology
Female
Graft vs Host Disease etiology
Graft vs Host Disease psychology
Humans
Lichen Planus, Oral etiology
Male
Middle Aged
Oral Ulcer etiology
Prospective Studies
Quality of Life
Xerostomia etiology
Bone Marrow Transplantation adverse effects
Graft vs Host Disease complications
Mouth Diseases etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6771
- Volume :
- 55
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- General dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 17333967