Back to Search
Start Over
A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis.
- Source :
-
Arthritis research & therapy [Arthritis Res Ther] 2007; Vol. 9 (2), pp. R27. - Publication Year :
- 2007
-
Abstract
- The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping the shared epitope (SE) hypothesis, was recently found relevant in terms of RA susceptibility and structural severity. We investigated the relevance of this new classification of HLA-DRB1 SE+ alleles in terms of rheumatoid factor (RF) and ACPA production in a sample of French RA patients. We studied 160 early RA patients included in a prospective longitudinal cohort of French Caucasian patients with recent-onset arthritis. RF, anticyclic citrullinated peptide 2 (anti-CCP2) and antideiminated human fibrinogen autoantibodies (AhFibA) were assessed in all patients at inclusion. The HLA-DRB1 gene was typed by PCR-sequence specific oligonucleotides probes (PCR-SSOP), and SE+ alleles were classified into four groups (S1, S2, S3P, S3D) according to the new classification. The new classification of HLA-DRB1 SE+ alleles distinguishes predisposing and protective alleles for RF, anti-CCP2 or AhFibA production. The presence of S2 or S3P alleles is associated with both RF, anti-CCP2 or AhFibA positivity, whereas the presence of S3D or S1 alleles appears to be protective for RF, anti-CCP2 or AhFibA positivity. The new classification of HLA-DRB1 SE+ alleles is relevant in terms of autoantibody production in early RA patients by differentiating predisposing and protective alleles for RF or ACPA production.
- Subjects :
- Alleles
Arthritis, Rheumatoid blood
Arthritis, Rheumatoid diagnosis
Biomarkers blood
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
HLA-DRB1 Chains
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Rheumatoid Factor blood
Antibody Formation genetics
Arthritis, Rheumatoid genetics
Autoantibodies blood
HLA-DR Antigens classification
HLA-DR Antigens genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6362
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Arthritis research & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 17328818
- Full Text :
- https://doi.org/10.1186/ar2131