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Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women's Ischemia Syndrome Evaluation (WISE).

Authors :
Wessel TR
Arant CB
McGorray SP
Sharaf BL
Reis SE
Kerensky RA
von Mering GO
Smith KM
Pauly DF
Handberg EM
Mankad S
Olson MB
Johnson BD
Merz CN
Sopko G
Pepine CJ
Source :
Clinical cardiology [Clin Cardiol] 2007 Feb; Vol. 30 (2), pp. 69-74.
Publication Year :
2007

Abstract

Background: Altered coronary reactivity is frequent in women with findings of myocardial ischemia without significant obstructive disease. This suggests a defect in coronary microvascular function. The adenosine-related component of this altered reactivity has been described in male and mixed gender populations, while the factors influencing this component of coronary reactivity in symptomatic women have received limited attention. Accordingly, the relationship between adenosine-related microvascular coronary reactivity and risk factors in symptomatic women evaluated for suspected ischemia remains uncertain.<br />Hypothesis: Abnormal coronary microvascular reactivity to adenosine is predicted by atherosclerosis risk factors in women.<br />Methods: As part of the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE), we investigated the relationship between risk factors and coronary microvascular reactivity as flow velocity reserve to intracoronary adenosine (CFVR(Ado)) in 210 women referred for angiography to evaluate suspected ischemia.<br />Results: Univariate analyses identified associations between CFVR(Ado) and multiple risk conditions; however, after adjusting for age, none remained significant. The best multivariable model using combinations of risk conditions to predict CFVR(Ado) yielded an R2 of only 0.18.<br />Conclusions: Among women with suspected ischemia, risk factors account for <20% of observed variability in CFVR(Ado). Therefore, other as yet unidentified factors must primarily account for coronary microvascular reactivity to adenosine.<br /> (Copyright (c) 2007 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
0160-9289
Volume :
30
Issue :
2
Database :
MEDLINE
Journal :
Clinical cardiology
Publication Type :
Academic Journal
Accession number :
17326061
Full Text :
https://doi.org/10.1002/clc.19