Back to Search
Start Over
Cytokines and chronic liver disease.
- Source :
-
Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2007 Feb-Apr; Vol. 18 (1-2), pp. 143-57. Date of Electronic Publication: 2007 Feb 26. - Publication Year :
- 2007
-
Abstract
- From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate a tolerogenic environment in this tissue. In this review we discussed the intrahepatic responses to different sorts of liver injury, such as hepatotrophic viruses, alcohol or putative self-antigens. In each case we analyzed the impact of different cytokines in the clinical outcome of the different pathological situations.
- Subjects :
- Animals
Autoantigens immunology
Chronic Disease
Dendritic Cells pathology
Endothelial Cells pathology
Hepatovirus immunology
Humans
Kupffer Cells pathology
Liver immunology
Liver injuries
Liver pathology
Liver Diseases pathology
Organ Specificity immunology
Cytokines immunology
Dendritic Cells immunology
Endothelial Cells immunology
Immune Tolerance
Kupffer Cells immunology
Liver Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1359-6101
- Volume :
- 18
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Cytokine & growth factor reviews
- Publication Type :
- Academic Journal
- Accession number :
- 17324606
- Full Text :
- https://doi.org/10.1016/j.cytogfr.2007.01.017