Back to Search
Start Over
Effect of anti-interferon-gamma and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 1992 Feb; Vol. 36 (2-3), pp. 105-15. - Publication Year :
- 1992
-
Abstract
- SJL/J mice challenged with myelin basic protein (MBP) in complete Freund's adjuvant (CFA) developed only mild chronic-relapsing experimental allergic encephalomyelitis (EAE) with very low incidence. However, treatment of challenged mice with anti-interferon-gamma (IFN-gamma) monoclonal antibody (mAb) determined severe disease in all cases. Similarly, in passive EAE, the addition of anti-IFN-gamma to the in vitro MBP-activated cells at the time of transfer led to significant disease exacerbation in all recipients. The disease enhancing effect was observed only when the mAb was given at the time of active challenge or of passive transfer, but not at later times. Anti-interleukin-2 (IL-2) antibody had only a marginal effect in the active induction, but drastically reduced the manifestations of passive EAE, even when mixed with a disease-enhancing dose of anti-IFN-gamma. These findings support the notion that IL-2 is required for disease induction whereas IFN-gamma plays a disease-limiting role early in the development of EAE.
- Subjects :
- Animals
Brain pathology
Encephalomyelitis, Autoimmune, Experimental pathology
Female
Immunotherapy, Adoptive
Interferon-gamma immunology
Interleukin-2 immunology
Mice
Mice, Inbred C57BL
Spinal Cord pathology
Antibodies, Monoclonal immunology
Encephalomyelitis, Autoimmune, Experimental prevention & control
Interferon-gamma physiology
Interleukin-2 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 36
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 1732276
- Full Text :
- https://doi.org/10.1016/0165-5728(92)90042-j