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Preparation and study on the solid inclusion complex of cloxacillin sodium with beta-cyclodextrin.
- Source :
-
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2007 Sep; Vol. 68 (1), pp. 108-12. Date of Electronic Publication: 2006 Nov 24. - Publication Year :
- 2007
-
Abstract
- The interaction of cloxacillin sodium with beta-cyclodextrin (beta-CD) has been studied by several analytical techniques, including (1)H NMR, fluorescence spectroscopy, infrared spectroscopy. In this paper, solid inclusion complex of cloxacillin sodium with beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, infrared spectroscopy and 1D, 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of cloxacillin sodium with beta-CD. The formation constant of complex was determined by fluorescence method and (1)H NMR. Spacial configuration of complex has been proposed on 2D NMR technique.
- Subjects :
- Anti-Bacterial Agents chemistry
Chemistry, Pharmaceutical methods
Drug Carriers
Fluorometry methods
Food Additives chemistry
Models, Chemical
Molecular Conformation
Spectrophotometry, Infrared methods
Cloxacillin chemistry
Magnetic Resonance Spectroscopy methods
Spectrometry, Fluorescence methods
beta-Cyclodextrins chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1386-1425
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
- Publication Type :
- Academic Journal
- Accession number :
- 17321790
- Full Text :
- https://doi.org/10.1016/j.saa.2006.10.058