Back to Search
Start Over
Effects of chronic sepsis on rat motor units: experimental study of critical illness polyneuromyopathy.
- Source :
-
Experimental neurology [Exp Neurol] 2007 Apr; Vol. 204 (2), pp. 741-7. Date of Electronic Publication: 2007 Jan 13. - Publication Year :
- 2007
-
Abstract
- Critical illness polyneuromyopathy (CIP) leads to major muscle weakness correlated with peripheral nerve and/or muscle alterations. Because sepsis seems to be the main factor, we used an experimental model of chronic sepsis in rats to study the localization of the first alterations on isolated motor units of soleus muscle. Seven days of chronic sepsis leads to a decrease in muscle force and an increase in muscle fatigability. Muscle twitch contraction time is also slower and all the motor units exhibit a slow profile in septic rats. Motor axon conduction velocity remains normal. We observed a significant increase in the latency between nerve and muscle action potentials but no modifications in the electromechanical delay. The first action of sepsis on motor units seems to be a delayed trigger of muscle action potential along with a muscle weakness but without nerve conduction impairment.
- Subjects :
- Animals
Body Weight physiology
Disease Models, Animal
Dose-Response Relationship, Radiation
Electric Stimulation methods
Electromyography methods
Female
Muscle Contraction physiology
Muscle Fatigue physiology
Neural Conduction physiology
Rats
Rats, Wistar
Motor Neurons physiology
Muscle Fibers, Skeletal physiology
Muscle, Skeletal pathology
Sepsis pathology
Sepsis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-4886
- Volume :
- 204
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 17316611
- Full Text :
- https://doi.org/10.1016/j.expneurol.2007.01.006