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Gastrointestinal polyposis syndromes.
- Source :
-
Current molecular medicine [Curr Mol Med] 2007 Feb; Vol. 7 (1), pp. 29-46. - Publication Year :
- 2007
-
Abstract
- Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS).
- Subjects :
- Adenomatous Polyposis Coli diagnosis
Adenomatous Polyposis Coli genetics
Adenomatous Polyposis Coli therapy
Adenomatous Polyposis Coli Protein genetics
Adenomatous Polyposis Coli Protein metabolism
Animals
Gastrointestinal Neoplasms diagnosis
Gastrointestinal Neoplasms genetics
Gastrointestinal Neoplasms therapy
Humans
Peutz-Jeghers Syndrome diagnosis
Peutz-Jeghers Syndrome genetics
Peutz-Jeghers Syndrome pathology
Peutz-Jeghers Syndrome therapy
Signal Transduction
Transforming Growth Factor beta metabolism
Adenomatous Polyposis Coli pathology
Gastrointestinal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1566-5240
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 17311531
- Full Text :
- https://doi.org/10.2174/156652407779940404