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Control of peripheral B-cell development.
- Source :
-
Current opinion in immunology [Curr Opin Immunol] 2007 Apr; Vol. 19 (2), pp. 143-9. Date of Electronic Publication: 2007 Feb 15. - Publication Year :
- 2007
-
Abstract
- Three subsets of mature B cells exist in mice: B-1, follicular and marginal zone B cells. The recruitment of newly formed transitional B cells into these compartments depends on signals emanating from the B-cell antigen receptor, possibly in response to (self-)antigen recognition. Recent evidence suggests that peripheral B-cell fate is controlled by B-cell antigen receptor signal strength, acting in concert with the cytokine B-cell activating factor. Other work indicates that peripheral B-cell development is orchestrated by a complex network of transcription factors, which drive B-cell subset differentiation, at the same time preventing mature B cells from undergoing trans-differentiation or premature terminal differentiation.
- Subjects :
- Animals
B-Cell Activation Factor Receptor genetics
Mice
Receptors, Antigen, B-Cell genetics
Transcription Factors metabolism
Transcription, Genetic
B-Cell Activation Factor Receptor physiology
B-Lymphocyte Subsets immunology
Gene Expression Regulation, Developmental
Lymphopoiesis genetics
Receptors, Antigen, B-Cell physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0952-7915
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current opinion in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 17303401
- Full Text :
- https://doi.org/10.1016/j.coi.2007.02.010