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Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives.

Authors :
Krueger AC
Madigan DL
Green BE
Hutchinson DK
Jiang WW
Kati WM
Liu Y
Maring CJ
Masse SV
McDaniel KF
Middleton TR
Mo H
Molla A
Montgomery DA
Ng TI
Kempf DJ
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Apr 15; Vol. 17 (8), pp. 2289-92. Date of Electronic Publication: 2007 Jan 27.
Publication Year :
2007

Abstract

Substituted 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed. It was found that the saturated alkane dialkyl units provided the most active analogs.

Details

Language :
English
ISSN :
0960-894X
Volume :
17
Issue :
8
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
17300933
Full Text :
https://doi.org/10.1016/j.bmcl.2007.01.072