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Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Apr 15; Vol. 17 (8), pp. 2289-92. Date of Electronic Publication: 2007 Jan 27. - Publication Year :
- 2007
-
Abstract
- Substituted 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed. It was found that the saturated alkane dialkyl units provided the most active analogs.
- Subjects :
- Alkanes
Antiviral Agents pharmacology
Hepacivirus enzymology
Inhibitory Concentration 50
Replicon drug effects
Structure-Activity Relationship
Antiviral Agents chemical synthesis
Benzothiadiazines chemical synthesis
Benzothiadiazines pharmacology
Hepacivirus drug effects
Viral Nonstructural Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 17300933
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.01.072