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Inhibition of histamine-induced bronchospasm in guinea pigs treated with Cecropia glaziovi Sneth and correlation with the in vitro activity in tracheal muscles.
- Source :
-
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2007 May; Vol. 14 (5), pp. 328-32. Date of Electronic Publication: 2007 Feb 12. - Publication Year :
- 2007
-
Abstract
- A standardized aqueous extract (AE) and a purified fraction (BuF) of Cecropia glaziovi Sneth leaves were tested in unrestrained guinea pigs challenged with histamine. Changes of the respiratory pressure and rate were recorded in a whole body plethysmograph before and after treatment. The concentration of histamine necessary to produce bronchospasm was increased by five-fold following administration of AE (1.0 g/kg p.o.), and by two-fold after treatment with the semi-purified procyanidin/flavonoids enriched BuF (0.1 g/kg p.o.). Both effects were blocked by previous treatment with propranolol (10.0 mg/kg i.p.). In vitro incubation of BuF (0.1-1.0 mg/ml) decreased by 13-55% the maximal response of guinea pig tracheal muscle to histamine, without significant change of EC50. The results confirmed old reports on the useful pulmonary effects of Cecropia extracts. The bronchodilation observed in vivo seems to be related to beta-adrenergic activity observed in vitro only with high concentrations of the purified extract.
- Subjects :
- Administration, Oral
Animals
Bronchial Spasm chemically induced
Bronchodilator Agents administration & dosage
Bronchodilator Agents therapeutic use
Dose-Response Relationship, Drug
Guinea Pigs
Histamine
Male
Muscle Contraction drug effects
Muscle, Smooth drug effects
Plant Extracts administration & dosage
Plant Extracts therapeutic use
Plant Leaves
Bronchial Spasm prevention & control
Bronchodilator Agents pharmacology
Phytotherapy
Plant Extracts pharmacology
Trachea drug effects
Urticaceae
Subjects
Details
- Language :
- English
- ISSN :
- 0944-7113
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 17298876
- Full Text :
- https://doi.org/10.1016/j.phymed.2006.12.022