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Oral ganciclovir versus low-dose valganciclovir for prevention of cytomegalovirus disease in recipients of kidney and pancreas transplants.
- Source :
-
Transplantation [Transplantation] 2007 Feb 15; Vol. 83 (3), pp. 290-6. - Publication Year :
- 2007
-
Abstract
- Background: The optimal regimen for prophylaxis of cytomegalovirus (CMV) disease after kidney and/or pancreas transplantation remains unclear. We compared the effectiveness of three months of oral ganciclovir (3 g/day) versus low-dose valganciclovir (450 mg/day) for CMV prophylaxis.<br />Methods: We performed a retrospective cohort study of patients at our center who received kidney and/or pancreas transplants between January 2000 and April 2003. We used a Cox proportional hazards model to examine the relationship between baseline covariates, including type of CMV prophylaxis, and time to development of CMV disease.<br />Results: Of the 500 patients (295 ganciclovir, 205 valganciclovir), 22 patients (4.4%) developed CMV disease (mean time to CMV disease, 163+/-85 days). Sixteen of the ganciclovir patients (5.4%) and six of the valganciclovir patients (2.9%) developed CMV disease (P=0.18). By CMV serostatus, the incidence of CMV disease during the first posttransplant year was 8.5% among donor-seropositive, recipient-seronegative (D+/R-) patients, 8.6% among D+/R+ patients, 2.9% among D-/R+ patients, 1.0% among D-/R- patients, and 0.9% among patients for whom documentation of CMV serostatus was incomplete. In the unadjusted Cox proportional hazards analysis, race/ethnicity, type of transplant, type of antiviral prophylaxis, CMV serostatus, and use of mycophenolate mofetil were each associated with risk of developing CMV disease. In the adjusted, multivariable model, only CMV serostatus was associated with development of CMV disease.<br />Conclusions: Three months of low-dose valganciclovir (450 mg/day) was as effective as ganciclovir (3 g/day) for prophylaxis of CMV disease after kidney and/or pancreas transplantation.
- Subjects :
- Administration, Oral
Adult
Antiviral Agents administration & dosage
Cohort Effect
Female
Ganciclovir administration & dosage
Humans
Male
Middle Aged
Retrospective Studies
Valganciclovir
Antiviral Agents therapeutic use
Cytomegalovirus Infections prevention & control
Ganciclovir analogs & derivatives
Ganciclovir therapeutic use
Kidney Transplantation
Pancreas Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 83
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 17297403
- Full Text :
- https://doi.org/10.1097/01.tp.0000251371.34968.ca