Back to Search
Start Over
Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2007 Mar; Vol. 86 (3), pp. 423-30. Date of Electronic Publication: 2007 Feb 06. - Publication Year :
- 2007
-
Abstract
- The aim of this study is to investigate the effects of baicalein on cognitive impairment and neuronal degeneration in a rat model of chronic cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). It was found that baicalein (2 or 4 mg/kg/day, i.p.) significantly improved 2VO-induced cognitive deficits and neuropathological changes. Biochemical and histological examinations revealed that baicalein reduced the increased activities of superoxide dismutase (SOD) and malondialdehyde (MDA), and attenuated the decreased activities of glutathione peroxidase (GPx) and catalase in 2VO rats. The results of the present observation suggest that baicalein has therapeutic potential for the treatment of vascular dementia, which is most likely related, at least in part, to its antioxidant action.
- Subjects :
- Animals
Antioxidants administration & dosage
Brain drug effects
Brain pathology
Brain Ischemia complications
Brain Ischemia metabolism
Brain Ischemia psychology
Carotid Artery, Common
Catalase metabolism
Cognition Disorders etiology
Cognition Disorders metabolism
Cognition Disorders psychology
Constriction
Dementia, Vascular drug therapy
Dementia, Vascular metabolism
Dementia, Vascular psychology
Disease Models, Animal
Flavanones administration & dosage
Glutathione Peroxidase metabolism
Humans
Malondialdehyde metabolism
Maze Learning drug effects
Neurons drug effects
Neurons pathology
Rats
Rats, Sprague-Dawley
Superoxide Dismutase metabolism
Antioxidants therapeutic use
Cognition Disorders drug therapy
Flavanones therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0091-3057
- Volume :
- 86
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 17289131
- Full Text :
- https://doi.org/10.1016/j.pbb.2006.11.005