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An enantioselective Brønsted acid catalyzed enamine Mannich reaction.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2007 Feb 21; Vol. 5 (4), pp. 606-9. Date of Electronic Publication: 2006 Dec 22. - Publication Year :
- 2007
-
Abstract
- An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H(8)-BINOL has been identified as the optimal catalyst, to afford versatile beta-amino aryl ketones in good yield and enantiomeric excess.
Details
- Language :
- English
- ISSN :
- 1477-0520
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17285167
- Full Text :
- https://doi.org/10.1039/b616143j