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Distribution of tocotrienols in rats fed a rice bran tocotrienol concentrate.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2007 Feb; Vol. 71 (2), pp. 464-71. Date of Electronic Publication: 2007 Feb 07. - Publication Year :
- 2007
-
Abstract
- To examine the distribution of rice bran tocotrienol (T3), we gave rice bran T3 to rats after considering an acceptable daily intake of vitamin E for humans. Male SD rats (5 weeks of age) were fed for 3 weeks on a commercial diet containing 6.4 mg of vitamin E per 100 g wt and additively received vitamin E or the vehicle (vitamin E-free corn oil) by oral intubation. The animals were randomly divided into 4 groups depending on the type of test diet: control (vehicle), non-T3 (no T3 + 4.3 mg of tocopherol (TOC)/kg body weight (b.w.)/day), low-T3 (0.8 mg T3 + 3.5 mg TOC/kg b.w./day), and high-T3 (3.2 mg T3 + 1.1 mg TOC/kg b.w./day). The control rats and rats in the non-T3, low-T3, and high-T3 groups took 4.3 and 8.6 mg of vitamin E/kg b.w./day, respectively. Rice bran gamma-T3 was significantly distributed to the adipose tissue and increased from 1.1 to 10.2 nmol/g of adipose tissue according to the rice bran T3 intake.
- Subjects :
- Animals
Antioxidants analysis
Body Weight drug effects
Chromans blood
Chromans pharmacokinetics
Chromatography, High Pressure Liquid
Diet
Lipid Peroxidation drug effects
Male
Phosphatidylcholines metabolism
Phosphatidylethanolamines metabolism
Phospholipids blood
Rats
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances analysis
Tissue Distribution
Tocopherols blood
Tocotrienols analysis
Vitamin E analogs & derivatives
Vitamin E blood
Vitamin E pharmacokinetics
Antioxidants pharmacokinetics
Oryza chemistry
Tocotrienols pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0916-8451
- Volume :
- 71
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17284857
- Full Text :
- https://doi.org/10.1271/bbb.60524