Back to Search
Start Over
Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 1992 Jan; Vol. 10 (1), pp. 134-42. - Publication Year :
- 1992
-
Abstract
- Purpose: This multicenter, double-blind, randomized trial was performed to determine the efficacy and safety of pamidronate disodium (APD) in comparison to etidronate disodium (EHDP) in the treatment of cancer-related hypercalcemia.<br />Patients and Methods: Sixty-five male and female adult patients with cancer and corrected calcium levels of greater than or equal to 12.0 mg/dL after 24 hours of hydration were randomized to receive either 60 mg APD given as a single 24-hour infusion or 7.5 mg/kg EHDP given as a 2-hour infusion daily for 3 days.<br />Results: APD normalized corrected calcium levels in 70% (21 of 30) of patients, whereas EHDP did so in 41% (14 of 34) of patients (P = .026). The mean corrected serum calcium level decreased from 14.6 to 10.5 mg/dL in the APD-treated group and from 13.8 to 11.6 mg/dL in the EHDP-treated group within the first week of treatment. There was no difference in response to APD in patients without versus those with bone metastases (78% v 67%). Both drugs were well tolerated.<br />Conclusion: This study demonstrated that a single 60-mg infusion of APD is safe and more effective than EHDP given at the dose of 7.5 mg/kg for 3 days in the treatment of cancer-related hypercalcemia.
- Subjects :
- Adult
Aged
Analysis of Variance
Calcium blood
Diphosphonates administration & dosage
Diphosphonates adverse effects
Double-Blind Method
Etidronic Acid administration & dosage
Etidronic Acid adverse effects
Female
Humans
Hypercalcemia etiology
Infusions, Intravenous
Male
Middle Aged
Neoplasms blood
Pamidronate
Diphosphonates therapeutic use
Etidronic Acid therapeutic use
Hypercalcemia drug therapy
Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 0732-183X
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 1727915
- Full Text :
- https://doi.org/10.1200/JCO.1992.10.1.134